مقایسه اثرات درمانی آتروپین و آتروپین + اکسیم در مسمومین ارگانوفسفره با علائم موسکارینی

          Organophosphate insecticides are the choice group  of all  insecticides,    now, and are the most  common cause of poisoning. Organophosphates    inhibit acetyl –choline esteras enzyme,specialy in parasympatic synapsies in    man,and cause muscarinic effects,they also act on somatic nerves and    autonomic gangelia to present nicotinic effects, and C.N.S manifestation    may also be demonstrated. Drug treatment in these patients include    atropine & oximes specially if nicotinic effects are   apparant,oximes will be    necessary. This investigation compares two different sorts of treatment as    Atropine & Atropine + Oxime in poisoned patient with organophosphates    showing muscarinic signs and symptoms.           This study is an experimental clinical trial and 140 patients being    poisoned by organophosphates were reffered to special ward of poisoning    of Sina-Hospital-hamadan, then they were divided into two randomized    groups and were treated with one of the two kinds of treatment.                                                                 The results of the treatment using one and two drugs were divided into 3    categories , i.e. complete recovery , recovery with complication (respiratory    infection) , and mortality. Complete recovery was 95.5 & 87.9% in cases who    received one and two drug therapy respectively. Recovery with    complication was seen in 4.1% and 7.6% of patients using one and two drug    therapy respectively. Mortality was and 4.5% in cases who received one    and two drug respectively.           Statistical calculations and examinations distinguished no expressive    diversity between these two kinds of treatment.( p- value > 0.05)